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巴亚斯古楞 教授 博士研究生导师

* 来源 : * 发布人 : admin * 发表时间 : 2009-07-10 * 浏览 : 16973
  

巴亚斯古楞  教授 博士研究生导师 


学术任职:

中华医学会消化病学分会青年委员会         副主任委员

中国医药生物技术协会组织生物样本库分会   全国委员

中华消化学会生物样本库与转化医学协作组   委员

福建省医学会消化病学分会肿瘤学组         副组长

教育及工作经历

1989年9月 - 1994年7月             北京中医药大学临床医疗系

1994年10月- 2000年3月         内蒙古赤峰市中蒙医院消化内科,医生

2000年4月 - 2002年3月             东京外国语大学

2002年4月 - 2006年3月           日本东京大学医学部消化内科攻读博士,并获得医学 博士学位,主要研究消化道肿瘤血管再生与骨髓干细胞诱导之间的关系

2006年4月- 2009年6月          美国哈佛大学医学院麻省总医院消化内科,

                             博士后研究者,主要从事炎症性肠病及消化

                            道肿瘤的分子发病学研究。

2009年7月- 至今                厦门大学附属中山医院消化内科

 

获奖情况

 

2005年: 获得国家留学基金管理委员会颁发的《国家优秀自费留学生荣誉称号及奖学金》
2005年: 日本罗塔利米山纪念奖学金 

2003-2004: 日本东京东急奖学金集团奖学金

 

研究方向

1.炎症性肠病的分子生物学研究(Interested in the discovery of genes and the molecular mechanisms of their function in the regulation of the intestinal epithelial cell barrier function, intestinal microbial recognition and mucosal host defense mechanisms, critical role of the dendritic cells in the antigen sampling and antigen presenting process)。
2.消化道肿瘤的分子发病学机制(Research projects focus on identifying some of the key molecular genetic alterations underlying gastrointestinal malignancies, particularly colon cancer)。

 

 发表论著

1.Guleng B, Arihiro S, Alonso C, Niess J, Gupta S, Fukazawa A, and Reinecker HC. Plasmacytoid dendritic cells in control of regulatory T cell function in intestinal    restitution. In submition.
2.Guleng B, Tateishi K, Ohta m, Ijichi H, Tanaka Y, Jazag A, Washida M, Morikane K, Fukushima Y, Yamori T, Tsuruo T, Kanai F, Kawabe T, Sata M, and Omata M.Blockade of the SDF-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a VEGF-independent manner. Cancer Res 65: (13). July 1, 2005.
3.Guleng B, Tateishi K, Ohta M, Asaoka Y, Jazag A, Lin LJ, Tanaka Y, Tada M, Seto M, Kanai F, Kawabe T and Omata M..Smoothened gene mutations found in digestive cancer have no aberrant Hedgehog signaling activity.J Gastroenterol. 2006 Dec; 41(12):1238-9. Epub 2007 Feb 6.
4.Guleng B, Tateishi k, Ohta M, Ijichi H, Jazag A, Tanaka Y, Ikenoue T, Asaoka Y,Imamura J, Fukushima Y, Morikane K, Miyagishi M, Taira K, Kanai F, Kawabe T, and Omata M.Cancer-derived VEGF plays no role in malignant ascites formation in the mouse.World J Gastroenterol, 11 (35). September 21, 2005.
5.Jazag A, Ijichi H, Kanai F, Imamura T, Guleng B, Ohta M, Imamura J, Tanaka Y,Tateishi K,Ikenoue T, Kawakami T, Arakawa Y, Miyagishi M, Taira K, Kawabe T,and Omata M.Smad4 Silencing in Pancreatic Cancer Cell Lines Using Stable RNA Interference and Gene Expression Profiles Induced by Transforming Growth Factor-β.Oncogene, 24(4): 662-671(2005).
6.Ikenoue T, Kanai F, Hikiba Y, Tanaka Y, Imamura J, Ohta M, Jazag A, Guleng B, Asaoka Y, Tateishi K, Kawakami T, Matsumura M, Kawabe T, Omata M.Functional consequences of mutations in a putative Akt phosphorylation motif of B raf in human cancers.Mol Carcinog, 43:59-63 (2005).
7. Tsuneo Ikenoue, Fumihiko Kanai, Yohko Hikiba, Toshiyuki Obata, Yasuo Tanaka,Jun Imamura, Miki Ohta, Amarsanaa Jazag, Bayasi Guleng, Keisuke Tateishi,Yoshinari Asaoka, Masayuki Matsumura, Takao Kawabe, and Masao Omata.Functional Analysis of PIK3CA Gene Mutations in Human Colorectal Cancer.Cancer Res 65: (11). June 1, 2005.
8. Ohta M, Tateishi K, Ueha S, Guleng B, Ikenoue T, Tanaka Y, Kanai F, Washida M,Sata M,Sudo T, Kawabe T, Matsushima K, and Omata M. Reduced p38a Mitogen-activated Protein Kinase Activity in Donor Grafts Accelerates Acute Intestinal Graft-versus-Host Disease in Mice. Eur J Immunol.;35 (7) Jul, 2005.
9. Jazag A, Kanai F, Ijichi H, Tateishi K, Ikenoue T, Tanaka Y, Ohta M, Imamura J, Guleng B, Asaoka Y, Kawabe T, Miyagishi M, Taira K, Omata M. Single small-interfering RNA expression vector for silencing multiple transforming growth factor-b pathway components. Nucleic Acids Res.33(15). Aug 19, 2005
10. Ohta M, Tateishi K, Ueha S, Guleng B, Ikenoue T, Tanaka Y, Kanai F, Washida M, Sata M, Sudo T, Kawabe T, Matsushima K, and Omata M. p53-Independent Negative Regulation of p21/CIP1 by Sonic Hedgehog-Gli1 Pathway in Gastric Cancer Cells. Cancer Res 65: (23). December 1, 2005
11. Y Tanaka, F Kanai, T Ichimura, K Tateishi, Y Asaoka, B Guleng, A Jazag, M Ohta,J Imamura, T Ikenoue, HIjichi , T Kawabe, T Isobe and M Omata.The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1.Oncogene, October 10, 2005.
12. Tateishi K, Ohta M, Guleng B, Ijichi H, Tanaka Y, Ikenoue T, Asaoka Y, Imamura J, Jazag A, Fukushima Y, Sata M, Miyagishi M, Taira K, Kanai F, Kawabe T, and Omata M. TRAIL-induced cell death cooperates with IFN-gamma activation in the graft-versus-tumor effect against colon tumors. Int J Cancer. 2006 May 1;118(9):2237-46.
13. Tateishi K, Ohta M, Kanai F, Guleng B, Tanaka Y, Asaoka Y, Tada M, Seto M, Jazag A, Lianjie L, Okamoto M, Isayama H, Kawabe T, and Omata M. Dysregulated expression of stem cell factor Bmi1 in precancerous lesions of the gastrointestinal tract. Clin Cancer Res. 2006 Dec 1;12(23):6960-6.
14. R-X Shao, N Kato, L-J Lin, R Muroyama, M Moriyama, T Ikenoue, H Watabe, M Otsuka, B Guleng, M Ohta, Y Tanaka, S Kondo, N Dharel, J-H Chang, H Yoshida,T Kawabe and M Omata Absence of tyrosine kinase mutations in Japanese colorectal cancer patients.Oncogene. 2007 Mar 29;26(14):2133-5. Epub 2006 Oct 2.
 
国际学术会议发表:
1. Guleng B, Arihiro S, Gupta S, Alonso C, Reinecker HC. Plasmacytoid dendritic cells in control of regulatory T cell function in intestinal inflammation. Oral presentation on sesstion of [T cell regulation in intestinal inflammation], abstract ID: 595429, DDW- 2009, May 30-June 4, Chicago, USA.
2. Guleng B, Arihiro S, Gupta S, Alonso C, Reinecker HC. Recruitment of a Distinct CD103+ DC Subset in Response to H. hepaticus Infection Responsible for Induction of Foxp3+ Tregs in the Small Intestine. Oral presentation on sesstion of [T cell regulation in intestinal inflammation], abstract ID: 444803, DDW- 2008, May 17-21, San Diego, USA.
3. Arihiro S, Niess J, Guleng B, Gupta S, Fukazawa A, and Reinecker HC. Dendritic Cell Recruitment in the Initiation and Recovery from Colitis. DDW- 2007, Washinton DC, USA.
4. Guleng B, Tateishi k, Ohta M, Ijichi H, Jazag A, Imamura T, Tanaka Y, Ikenoue T, Kanai F, Kawabe T, Omata M. Increased Mobilization of Bone Marrow Derived Endothelial Progenitor Cells in the Peripheral Blood with Colon Cancer Progression. American Gastroenterological Association, New Orleans, USA, May 15-20, 2004. [Program]. DDW 2004, P-460.
5. Guleng B, Tateishi k, Ohta M, Ijichi H, Jazag A, Imamura T, Tanaka Y, Ikenoue T, Kanai F, Kawabe T, Omata M. The 3rd International Conference on Gastroenterological Carcinogenesis, Oral presentation, Sapporo, Hokkaido, Japan. Increased Mobilization of Bone Marrow Derived Endothelial Progenitor Cells in the Peripheral Blood with Colon Cancer Progression. [Abstract]. ICGC 2004, IO-10.
6. Guleng B, Tateishi K, Ohta m, Ijichi H, Tanaka Y, Jazag A, Washida M, Morikane K, Fukushima Y, Yamori T, Tsuruo T, Kanai F, Kawabe T, Sata M, and Omata M. DDW-Japan 2004, Fukuoka, Japan, October 21-24, 2004. Blocking of SDF-1/CXCR4 axis attenuates mouse subcutaneous tumor growth by inhibiting tumor vascular formation. [Abstract] Japanese Journal of Gastroenterology, 2004; 101(suppl): P-772.
7. Guleng B, Tateishi K, Ohta m, Ijichi H, Tanaka Y, Jazag A, Washida M, Morikane K,Fukushima Y, Yamori T, Tsuruo T, Kanai F, Kawabe T, Sata M, and Omata M. The 14th meeting of Japanese Society for Gastroenterological Carcinogenesis. Kanazawa, Japan, 2003. Contribution of bone-marrow-derived endothelial progenitor cells with colon cancer progression. [Program] JSGC 2003, P-139
8. Guleng B, Tateishi K, Ohta m, Ijichi H, Tanaka Y, Jazag A, Washida M, Morikane K, Fukushima Y, Yamori T, Tsuruo T, Kanai F, Kawabe T, Sata M, and Omata M. DDW-Japan 2003, Osaka, Japan, October 15-17, 2003. Analysis of the bone marrow derived endothelial progenitor cells in colon cancer model. [Abstract] Japanese Journal of Gastroenterology, 2003; 100:(suppl): P-680

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